CAN_369 |
| origin: |
Probing the N-Terminal beta-Sheet Conversion in the Crystal Structure of the Human Prion Protein Bound to a Nanobody |
| author: |
Abskharon, R.N., Giachin, G., Wohlkonig, A., Soror, S.H., Pardon, E., Legname, G., Steyaert, J. |
| patent: |
no |
| patent_application_number: |
null |
| CDR1_seq: |
null |
| CDR1_length: |
|
| CDR2_seq: |
null |
| CDR2_length: |
|
| CDR3_seq: |
null |
| CDR3_lentgh: |
|
| protein_seq: |
AAQLQESGGGLVQPGGSLRLSCAASGRTFSSYNMGWFRQAPGKGREFVASITSSGDKSDYTDSVKGRFTISRDNAKNTMY
LQMNNLKPEDTATYYCARGLGIYIIRARGGYDHWGQGTQVTVSSHHHHHH
|
| DNA_seq: |
null |
| PubMed_ID: |
24400836 |
| PDB_ID: |
4N9O |
| PDB_deposition_date: |
2013-10-21 |
| PDB_released_date: |
2014-01-22 |
| resolution: |
1.5Ã…
|
| source_organism: |
Lama glama |
| experiment_method: |
llama immunization,library construction,screen,express |
| antigen: |
the human prion protein |
| antigen_chain: |
null |
| antigen_seq: |
null |
| function: |
inhibits prion propagation |
| validationORprediction: |
Experimentally Validated |
| epitope: |
null |
| bacteria_family: |
Escherichia coli |
| publication: |
J Am Chem Soc. 2014 Jan 22;136(3):937-44. doi: 10.1021/ja407527p. Epub 2014 Jan 8. |
|
